Could the induction of trained immunity by β-Glucan serve as a defence against COVID-19? 


Anne Geller, Jun Yan

Immunol. 2020 Jul 14;11:1782. doi: 10.3389/fimmu.2020.01782. Ecollection20202

As the SARS-CoV-2 virus wreaks havoc on populations, primary care infrastructures and economies around the world, finding ways to protect healthcare workers and boost immune responses in the general population, while waiting for a vaccine to definitively eradicate the infection, seems a priority. 

Recent studies show that innate immunity may possess a form of memory, called Trained Immunity (TRIM) and that certain substances such as β-Glucan, with a direct stimulatory action on the immune response, may also behave as a training agent for innate immunity, resulting in more robust immune responses, when cells of this immune system come into contact with a secondary heterologous stimulus. 

Understanding the exact mechanism of the immune response to SARS-CoV-2 will likely guide therapeutic and preventive interventions in the future. It will also be very important to understand why some patients develop a hyperinflammatory syndrome, as this will determine prevention and treatment strategies. 

It has been shown that oral β-Glucan can be an efficient, cost-effective and safe way to support the immune response to SARS-CoV-2 and prevent severe clinical pictures.